Omar Fayed made his competitive Frosinone debut and converted a shootout penalty, but Sassuolo advanced following a 1-1 Coppa Italia draw.
Omar Fayed entered the round-of-32 tie in the 62nd minute, replacing the booked Kevin Akpoguma with the score level at the Mapei Stadium.
Benjamin Domínguez had given Sassuolo the lead in the 36th minute after capitalising on an Akpoguma mistake and beating Guillaume Desplanches.
Aleksa Terzić equalised during first-half stoppage time, meeting Luis Hasa’s pass with a left-footed strike from outside the penalty area.
Frosinone had two efforts disallowed after the interval. Daniel Bîrligea was denied by an offside decision before Matteo Cichella found the net in the 74th minute.
However, the referee overturned Cichella’s goal following a VAR review after ruling that Fayed had fouled Bowie earlier in the move.
Neither team found a winner before the final whistle, sending the match directly to penalties without extra time.
Fayed converted his attempt during the shootout. However, Wisdom Amey and Hasa failed from the spot as Sassuolo completed a 5-4 penalty victory.
The result eliminated Frosinone and sent Sassuolo into a round-of-16 meeting with Juventus.
Fayed’s Coppa Italia appearance came two weeks after he completed a permanent transfer from Fenerbahçe. The 23-year-old signed a four-year contract on August 19.
The former Arab Contractors defender had not appeared during Frosinone’s opening two Serie A matches, leaving him still awaiting his league debut in Italy.